Kvasny Prum. 2015; 61(4): 114-119 | DOI: 10.18832/kp2015014

The occurrence of "emerging" mycotoxins in brewing raw materials.Peer-reviewed article

Karolína BENEŠOVÁ, Martina ČUMOVÁ, Sylvie BĚLÁKOVÁ, Renata MIKULÍKOVÁ, Zdeněk SVOBODA
1 VÚPS, a. s., Sladařský ústav Brno, Mostecká 7, 614 00 Brno
2 ÚKZÚZ, Národní referenční laboratoř, Hroznová 2, 656 00 Brno

"Emerging" mycotoxins are newly appearing mycotoxins, the existence of which was previously unknown. Fusaproliferin, beauvericin, enniatins, and moniliformin are metabolites of the most frequent fungi of Fusarium spp. Only limited data on these toxins exist, however, namely enniatins were detected in cereals at relatively high concentrations. Currently, research and monitoring of these mycotoxins in various raw materials and derived products have been conducted. This study summarizes the latest knowledge about the occurrence of "emerging" mycotoxins in brewing materials and their transmission to beer.

Keywords: emerging mycotoxins, cereals, barley, malt, beer, pathogens, Fusarium

Received: December 16, 2014; Accepted: February 11, 2015; Published: April 1, 2015 

References

  1. Bolechová, M., Benešová, K., Běláková, S., Čáslavský, J., Pospíchalová, M., Mikulíková, R., 2015: Determination of seventeen mycotoxins in barley and malt in the Czech Republic. Food Control 47, 108 - 113. DOI: 10.1016/j.foodcont.2014.06.045 Go to original source...
  2. Burmeister, H. R., Ciegler, A., Vesonder, R. F., 1979: Moniliformin, a metabolite of Fusarium moniliforme NRRL 6322: Purification and toxicity. Appl. Environ. Microbiol. 37: 11 - 13. Go to original source...
  3. Cole, R. J., Kirksey, J. W., Cutler, H. G., Doupnik, B. L. Peckham, J. C., 1973: Toxin from Fusarium moniliforme: effect on plants and animals. Science 179: 1324 - 1326. Go to original source...
  4. Creppy, E. E., 2002: Update of survey, regulation and toxic effects of mycotoxins in Europe. Toxicol. Lett. 127 (1-3): 19 - 28. Go to original source...
  5. Ezekiel, Ch. N., Abia, W. A., Ogara, I. M., Sulyok, M., Warth, B., Krska, R., 2015: Fate of mycotoxins in two popular traditional cereal- -based beverages (kunu-zaki and pito) from rural Nigeria. LWT - Food Sci. Technol. 60 (1): 137 - 141. DOI: 10.1016/j.lwt.2014.08.018 Go to original source...
  6. Fakhrunnisa, Hasmhi, M. H., Ghaffar, A., 2006: Seed-borne mycoflora of wheat, soghum and barley. Pak. J. Bot. 38: 185 - 192.
  7. Fornelli, F., Minervini, F., Logrieco, A., 2004: Cytotoxicity of fungal metabolites to lepidopteran (Spodoptera frugiperda) cell line (SF-9). J. Invertebr. Pathol. 85: 74 - 79. Go to original source...
  8. Grove, J. F., Pople, M.: 1980.The insecticidal activity of beauvericin and the enniatin complex. Mycopathologia 70: 103 - 105. Go to original source...
  9. Hu, L., Gastl, M., Linkmeyer, A., Hess, M., Rychlik, M., 2014: Fate of enniatins and beuavericin during the malting and brewing process determined by stable isotope dilution assays. LWT- Food Sci.Technol. 56: 469 - 477. DOI: 10.1016/j.lwt.2013.11.004 Go to original source...
  10. Jestoi, M., 2008: Emerging Fusarium-mycotoxins fusaproliferin, beauvericin, enniatins, and moniliformin - A review. Crit. Rev. Food Sci. Nutr. 48: 21 - 49. Go to original source...
  11. Jestoi, M., Rokka, M., Yli- Mantila T., Parikka, P., Rizzo, A. Peltonen, K., 2004: Presence and concentration of the Fusarium - related mycotoxins beauvericin, enniatins nad moniliformin in Finnish grain samples. Food Addit Contam. 21: 794 - 802. Go to original source...
  12. Logrieco, A., Moretti, A., Fornelli, F., Fogliano., V. Ritieni, A., Caiaffa, M. F., Randazzo, G., Bottalico, A., Macchia, L., 1996: Fusaproliferin production of Fusarium subglutinans and its toxicity to Artemia Salina, SG-9 insects cells, and IRAC/LCL 171 human B lymphocytes. Appl. Environ. Microbiol. 60: 3378 - 3384. Go to original source...
  13. Meca, G., Zinedine, A., Blesa, J., Font, G., Manes, J., 2010: Further data on the pressence of Fusarium emerging mycotoxins enniatins, fusaproliferin and beauvericin in cereals available on Spanish Markets. Food Chem. Toxicol. 48: 1412 - 1416. DOI: 10.1016/j. fct.2010.03.010 Go to original source...
  14. Munkvold, G., Stahr, H. M., Logriego, A., Moretti, A. a Ritieni, A., 1998: Occurence of fusaproliferin an beauvericin in Fusarium-contaminated livestock feed on Iowa, Appl. Environ. Microbiol.: 64, 3923 - 3926. Go to original source...
  15. Ojcius, D. M., Zychlinsky, A., Zheng, L. M., Young, J. E., 1991: Ionophore induced apoptosis: role of DNA fragmentation and calcium fluxes. Exp Cell Res. 197 (1): 43 - 49. Go to original source...
  16. Oueslati, S., Meca, G., Mliki, A., Ghorbel, A., Mañes, J., 2011: Determination of Fusarium mycotoxins enniatins, beauvericin and fusaproliferin in cereals and derived products from Tunisia. Food Control. 22: 1373-1377. DOI: DOI: 10.1016/j.foodcont.2011.02.015 Go to original source...
  17. Polišenská, I., Jirsa, O., Salava, J., 2009: Fusarium mycotoxins and fusarium pathogens in cereals harvested in 2009. Obilnářské listy 17: 3 - 6.
  18. Richard, J. L., 2007: Some major mycotoxins and their mycotoxicoses - An overview. Int. J. Food Microbiol. 119 (1-2): 3 - 10. Go to original source...
  19. Ritieni, A., Monti, S. M., Randazzo, G., Logrieco, A., Moretti, A., Pelluso, G., Ferracane, R., Fogliano., V., 1997: Teratogenic effectsof fusaproliferin on chicken embrylos. J. Agric. Food Chem. 45: 3039 - 3043. DOI: 10.1021/jf960890v Go to original source...
  20. Santini, A., Ritieni, A., Fogliano, V., Randazzo, G., Mannina, L., Logrieco, A., Benedetti, E., 1996: Structure and absolute stereochemistry of fusaproliferin, a toxic metabolite from Fusarium proliferatum. J. Nat. Prod. 59 (2): 109 - 112. DOI: 10.1021/np960023k Go to original source...
  21. Santini, A., Meca, G., Uhlig, s., Ritieni, A., 2012: Fusaproliferin, beauvericin and enniatins: occurence in food - review.World Mycotoxin J. 5: 71 - 81. DOI: 10.3920/WMJ2011.1331 Go to original source...
  22. Scott, P. M., 1996: Mycotoxins transmitted into beer from contaminated grains during brewing. Journal of the AOAC International 79: 875 - 882. Go to original source...
  23. Sifou, A., Meca, G., Serrano, A. B., Mahine, N., El Abidi, A., Manes, J., El Azzouzi, M., Zinedine, A.: 2011, First report on zhe presence of emerging Fusarium mycotoxins enniatins (A, A1, B, B1), beauvericin and fusaproliferin in rice on Morrocan retal markets. Food Control, 22: 1826 - 1830. DOI:10.1016/j.foodcont.2011.04.019 Go to original source...
  24. Speijers, G. J. A., Speijers, M. H. M., 2004: Combined toxic effects of mycotoxins. Toxicol. Lett. 153 (1): 91 - 98. DOI:10.1016/j.toxlet.2004.04.046 Go to original source...
  25. Springer, J. P., Clardy, J., Richard J. C., Kirksey, J. W., Hill, R. K., Carlson, R. M., Isidor, J. L., 1974: Structure and synthesis of moniliformin, a novel cyclobutane microbial toxin. J. Am. Chem. Soc. 96 (7): 2267 - 2268. Go to original source...
  26. Uhlig, S., Torp, M., Jarp, J., Parich, A., Gutleb, A. C., Krska, R., 2004: Moniliformin in Norwegian grain. Food Addit Contam. 21 (6): 598 - 606. Go to original source...
  27. Václavíková, M., Malachová, A., Veprikova, Z., Dzuman, Z., Zachariasova, M., Hajslova, J., 2013: 'Emerging' mycotoxins in cereals processing chains: changes of enniatins during beer and bread making. Food Chemistry 136: 750 - 757. DOI: 10.1016/j.foodchem.2012.08.031 Go to original source...
  28. Vaughan, A., Sullivan, T. O., Sinderen, D. V., 2005: Enhancing the Microbiological Stability of Malt and Beer - A Review. J. Inst. Brew. 111: 355 - 371. DOI: 10.1002/j.2050-0416.2005.tb00221.x Go to original source...
  29. Verstraete, F., 2009: EU food safety legislation with focus on contaminants: Challenges for food research, in Food Research in Support to Science - Base Regulations: Challenges for Producers and Customers. 21-22th April, 2009, Prague.
  30. Wolf-Hall, C. E., 2007: Mold and mycotoxin problems encountered during malting and brewing. Int. J. Food Microbiol. 119: 89 - 94. DOI:10.1016/j.ijfoodmicro.2007.07.030 Go to original source...
  31. Zinedine, A., Meca, G., Manes, J., Font, G.: 2011. Further data on the occurence of Fusarium emerging mycotoxins enniatins (A, A1, B, B1), fusaproliferin and beauvericin in raw cereals commercialized in Morocco. Food Control 22: 1 - 5. DOI :10.1016/j.foodcont.2010.05.002 Go to original source...